FB2025_01 , released February 20, 2025
Allele: Hsap\APCSUAS.cAa
Open Close
General Information
Symbol
Hsap\APCSUAS.cAa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Andersson
FlyBase ID
FBal0323149
Feature type
allele
Associated gene
Hsap\APCS
Associated Insertion(s)
Carried in Construct
P{UAS-hAPCS.A}
Also Known As
UAS-SAP
Key Links
Transgenic product class
wild_type
(Andersson et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Andersson et al., 2013)
Mutagen
in vitro construct
(Andersson et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-hAPCS.A}
Cytology
Description

UASt regulatory sequences drive expression of Hsap\APCS.

(Andersson et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\APCS
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  amyloidosis
      modeled by Hsap\LYZF57I.UAS.Tag:SS(nec)
      (Helmfors et al., 2016)
      ameliorates  transthyretin amyloidosis
      modeled by Hsap\TTRA.UAS
      (Andersson et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\APCSScer\UAS.cAa under the control of Scer\GAL4nSyb.PS does not induce apoptosis in the adult brain.

      (Helmfors et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Hsap\LYZScer\UAS.T:SS-nec and Hsap\APCSScer\UAS.cAa under the control of Scer\GAL4nSyb.PS does not affect adult lifespan, nor does it cause any cell death in the adult brain.

      The short lifespan and the increased apoptosis levels in the brains of adult flies expressing Hsap\LYZF57I.Scer\UAS.T:SS-nec under Scer\GAL4nSyb.PS are both rescued by co-expression of Hsap\APCSScer\UAS.cAa.

      (Helmfors et al., 2016)

      The frequency of the dragged-wing posture phenotype as well as the retinal degeneration observed in the adult flies expressing Hsap\TTRA.Scer\UAS under the control of Scer\GAL4GMR.PF is much reduced by co-expression of Hsap\APCSScer\UAS.cAa.

      (Andersson et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\APCSScer\UAS.cAa
      Hsap\APCSUAS.cAa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Andersson
      Secondary FlyBase IDs
        References (3)