FB2025_01 , released February 20, 2025
Allele: Dmel\TrpA1-CD-G4
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General Information
Symbol
Dmel\TrpA1-CD-G4
Species
D. melanogaster
Name
FlyBase ID
FBal0323539
Feature type
allele
Associated gene
Dmel\TrpA1
Associated Insertion(s)
TI{GAL4}TrpA1-CD
Carried in Construct
Also Known As
trpA1-CDGAL4
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
gene targeting by homologous recombination
(Luo et al., 2017)
Progenitor genotype
Associated Insertion(s)
TI{GAL4}TrpA1-CD
Cytology
Description

732bp deletion that spans the translation initiation codon common to the C and D isoforms of TrpA1, preventing expression of these two isoforms. Sequence encoding a GAL4 driver and a w+mW.hs marker have been inserted in place of the deleted sequence. The GAL4 driver acts as a reporter of expression of the TrpA1 C and D isoforms.

(Luo et al., 2017)
Allele components
Component
Use(s)
Inserted element
TI{GAL4}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      TrpA1-CD-G4 mutant larvae do not have reduced rolling (escape) behavior in response to noxious temperature increases, compared to controls.

      (Luo et al., 2017)

      TrpA1CD-G4 homozygous mutant third instar larvae show impaired temperature selection and unlike controls display no strong preference for cooler temperatures (18[o]C) in a temperature gradient.

      (Sokabe et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TrpA1-CD-G4
      TrpA1CD-G4
      Name Synonyms
      Secondary FlyBase IDs
        References (3)