FB2025_01 , released February 20, 2025
Allele: Dmel\sxcH596F.UAS
Open Close
General Information
Symbol
Dmel\sxcH596F.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0323900
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UAS regulatory sequences drive expression of sxc carrying the amino acid replacement H596F (sxc protein carrying this mutation has been shown to retain a small amount of catalytic activity in vitro).

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing sxcH596F.Scer\UAS under the control of Scer\GAL4tub.PU partially rescues the lethality of sxc1/sxc6 transheterozygotes but the majority of the surviving adults has wing defects which consist mostly of ectopic veins; the rest have normal wing morphology; these surviving females have viable progeny.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

The expression of sxcH596F.Scer\UAS under the control of Scer\GAL4tub.PU partially rescues the pharate adult stage lethality of sxc1/sxc6 heterozygotes but the majority of the surviving adults has wing defects which consist mostly of ectopic veins; the rest have normal wing morphology.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
sxcH596F.Scer\UAS
sxcH596F.UAS
Name Synonyms
Secondary FlyBase IDs
    References (1)