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General Information
Symbol
Dmel\Tnks503
Species
D. melanogaster
Name
FlyBase ID
FBal0324220
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of P{EP}G9172 results in deletion of the Tnks transcription and translation initiation sites (-20 to +1839 with reference to the Tnks transcriptional start site); approximately 3.3K nucleotides from P{EP}G9172 remain at this site.

Insertion components
P{?EP}Tnks503
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Tnks19/Tnks503 transheterozygous mutants eclose at normal rates and are viable, but adults display a significant increase in mortality when maintained on a sucrose only diet (5% sucrose (v/v) in aqueous solution), as compared to controls.

Tnks19/Tnks503 transheterozygous mutant adult midguts show a significant increase in the numbers of intestinal stem cells, of intestinal progenitor cells and of mitotic cells, but similar apoptotic levels, as compared to controls; these phenotypes become more severe with age.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The increase in the numbers of intestinal progenitor cells and mitotic cells present in Tnks19/Tnks503 transheterozygous mutant adult midguts is suppressed by AxnS044230 heterozygosity; the increase in the numbers of intestinal stem cells and mitotic cells observed in Tnks19/Tnks503 transheterozygous mutant adult midguts are suppressed by expressing either upd3KK110348 or upd3GD6811 under the control of Scer\GAL4Myo31DF-NP0001.

Expression of AxnScer\UAS.T:SV5\V5 under the control of Scer\GAL471B in the Tnks19/Tnks503 background leads to morphological wing (notches, loss of wing margin, ectopic bristles) and ventral abdomen (loss of sternite and sternite bristles, reduced size of the sternites that remained, expansion of pleura) defects in adults.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expressing TnksScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Myo31DF-NP0001 significantly rescues the increase in the numbers of stem cells and mitotic cells observed in the adult midgut of Tnks19/Tnks503 transheterozygous mutant adults.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)