FB2025_01 , released February 20, 2025
Allele: Dmel\Ythdc1UAS.Tag:HA
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General Information
Symbol
Dmel\Ythdc1UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0324793
Feature type
allele
Associated gene
Dmel\Ythdc1
Associated Insertion(s)
Carried in Construct
P{UAS-Ythdc1.HA}
PBac{UAS-Ythdc1.HA}
Key Links
Transgenic product class
wild_type
(Haussmann et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Haussmann et al., 2016)
Mutagen
in vitro construct
(Haussmann et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-Ythdc1.HA}
PBac{UAS-Ythdc1.HA}
Cytology
Description

UAS regulates expression of the Ythdc1 ORF, with the translation initiation site from the Adh gene and two copies of a Tag:HA epitope added to the end.

(Haussmann et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Ythdc1
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of YT521-BScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tub.PU is male lethal.

      (Haussmann et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The male lethality of flies expressing YT521-BScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tub.PU is partially rescued by combination with Ime4Δ22-3 in a homozygous state (although the viability of such males is still much lower compared to controls).

      (Haussmann et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      YT521-BScer\UAS.T:Ivir\HA1
      Ythdc1Scer\UAS.T:Ivir\HA1
      Ythdc1UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (4)