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General Information
Symbol
Dmel\Nc73EFMI06026-TG4.1
Species
D. melanogaster
Name
FlyBase ID
FBal0325008
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

The Mi{MIC} RMCE cassette in Mi{MIC}Nc73EFMI06026 is replaced by a T2A-GAL cassette (includes a splice acceptor, linker, ribosomal skipping T2A peptide sequence, Scer\GAL4 coding sequence, polyadenylation signal and a splice donor) in a common coding intron of Nc73EF; also functions as a Scer\GAL4 under the endogenous Nc73EF promoter.

The RMCE cassette of the Mi{MIC}Nc73EFMI06026 insertion has been replaced with a Trojan-GAL4 cassette. The insertion is in within the coding intron of all annotated transcripts of Nc73EF and is predicted to express GAL4 in the same pattern as Nc73EF.

Insertion components
Mi{Trojan-GAL4.1}Nc73EFMI06026-TG4.1
Product class / Tool use(s)
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 

A neurodegenerative disorder has been ascribed to a mutation in the OGDH gene (a human ortholog of Nc73EF) in a patient. Mutations in three known disease-related genes have also been identified in this patient but their known clinical symptoms do not match the phenotype of the patient.

Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The lethality of Nc73EFMI06026-TG4.1 mutants can be rescued by Scer\GAL4Nc73EF-MI06026-TG4.1-driven (= inherent Gal4 in the Nc73EFMI06026-TG4.1 allele) expression of Hsap\OGDHScer\UAS.T:Zzzz\FLAG but not Hsap\OGDHS791L.Scer\UAS.T:Zzzz\FLAG.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Nc73EFMI06026-TG4.1
Name Synonyms
Secondary FlyBase IDs
    References (3)