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General Information
Symbol
Dmel\PGRP-SDsk1
Species
D. melanogaster
Name
FlyBase ID
FBal0325049
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

11 bp deletion at the 5' end of PGRP-SD causes a frameshift and early translation termination.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

11bp deletion in PGRP-SD (nucleotides 129-139); this induces a frameshift, causing a premature stop codon and leading to a peptide of 50 residues lacking the PGRP domain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

PGRP-SDsk1 mutant flies are viable and fertile, their adult lifespan at 29[o]C is comparable to wild-type and they do not display any defects in bacterial elimination upon infection with either Gram-negative Erwinia carotovora or Gram-positive Listeria monocytogenes. They also do not exhibit any increased sensitivity to infections with bacteria Enterococcus faecalis, Streptococcus pyogenes or Erwinia carotovora or fungi Beauveria bassiana and Aspergillus fumigatus but show reduced survival rate upon infection with either Pseudomonas entomophila or Bacillus subtilis relative to wild-type controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Suppressor of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The reduced survival rate of either PGRP-SAseml or GNBP1e03371 mutant adults upon infection with either Staphylococcus aureus or Streptococcus pyogenes is not worsened further by combination with PGRP-SDsk1.

The decreased lifespan at 29[o]C as well as the precocious lethality upon Erwinia carotovora infection characteristic for PGRP-LBΔ mutant adults is rescued in PGRP-LBΔ;PGRP-SDsk1 double mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)