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General Information
Symbol
Hsap\TBX2UAS.Tag:FLAG
Species
H. sapiens
Name
FlyBase ID
FBal0325058
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a Hsap\TBX2 cDNA that is tagged at the C-terminal end with 3 copies of Tag:FLAG.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
model of  cancer
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
model of  cancer
is NOT ameliorated by TimpUAS.cPa
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of Hsap\TBX2Scer\UAS.T:Zzzz\FLAG, under the control of Scer\GAL4dpp.PU throughout development, or in combination with gal80[ts] to restrict expression to the larval stage results in some cells crossing the anterior-posterior compartment border and displaying actin protrusions after 15h of gal80[ts]-regulated expression; expression under the control of Scer\GAL4C-765 results in a proportion of disc cells becoming embedded in the extracellular matrix and basally delaminating, as cells extrude from the epithelium and accumulate on the other side of the basal membrane, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The co-expression of TimpScer\UAS.cPa does not significantly suppress the long distance cell migration and scattering, and the basal delamination of cells resulting from the expression of Hsap\TBX2Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4dpp.PU and Scer\GAL4C-765, respectively.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Hsap\TBX2Scer\UAS.T:Zzzz\FLAG
Hsap\TBX2UAS.Tag:FLAG
Name Synonyms
Secondary FlyBase IDs
    References (1)