FB2025_01 , released February 20, 2025
Allele: Dmel\Khc401.UASp.Tag:MCP
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General Information
Symbol
Dmel\Khc401.UASp.Tag:MCP
Species
D. melanogaster
Name
FlyBase ID
FBal0325535
Feature type
allele
Associated gene
Dmel\Khc
Associated Insertion(s)
Carried in Construct
P{UASp-Khc.401.MCP}
Key Links
Transgenic product class
inframe_deletion
(Gáspár et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Gáspár et al., 2017)
Mutagen
in vitro construct
(Gáspár et al., 2017)
Progenitor genotype
Carried in construct
P{UASp-Khc.401.MCP}
Cytology
Description

UASp regulatory sequences drive expression of amino acids 1-401 of Khc (this is the minimal sequence required for processive movement), tagged at the C-terminal end with Tag:MCP.

(Gáspár et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Khc
Tagged with
Tag:MCP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Scer\GAL4VP16.osk/Khc401.UASp.Tag:MCP is a suppressor of oocyte phenotype of Tm1eg9/Tm1eg1

      (Gáspár et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Khc401.Scer\UAS.P\T.T:MS2\MCP under the control of Scer\GAL4osk.T:Hsim\VP16 rescues the impaired plus-end-directed motility of osk messenger ribonucleoprotein particles (restoring the dominance of plus-end-directed runs over the minus-end-directed runs) and the posterior pole localization of osk mRNA in the mutant oocytes.

      (Gáspár et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Khc401.Scer\UAS.P\T.T:MS2\MCP
      Khc401.UASp.Tag:MCP
      Khc401.UASp.Tag:MS2-CP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)