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General Information
Symbol
Dmel\Myd88VDRC.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0325560
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an Myd88 RNAi construct.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
exacerbates  cancer
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of Myd88VDRC.cUa under the control of Scer\GAL4c564 blocks the normal inflammatory response to Gram-positive bacterial infection (assessed by the expression levels of Drosomycin), but has no significant effect in basal (non-infected) conditions, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The decrease in the number of cells within the Scer\GAL4Myd88-NP6394 driver's expression domain in the pupal ventral nerve cord (assayed using a nuclear histone-reporter) observed upon expression of wekScer\UAS.ORF.GW.T:Ivir\HA1 is exacerbated further by co-expression of Myd88VDRC.cUa.

The apoptosis observed in dlg1A40.2 mutant wing disc tumors is virtually abrogated by the expression of Myd88VDRC.cUa under the control of either Scer\GAL4ppl.PP, Scer\GAL4Cg.PA or Scer\GAL4Lsp2.PH.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Myd88VDRC.cUa
Name Synonyms
Secondary FlyBase IDs
    References (3)