FlyBase Allele Report: Dmel\Myd88[VDRC.cUa]

General Information

Symbol

Dmel\Myd88^VDRC.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0325560

Feature type

allele

Associated gene

Dmel\Myd88

Associated Insertion(s)

Carried in Construct

P{VDRC.Myd88.U}

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

in vitro construct - regulatory fusion

(Kumar et al., 2016)

in vitro construct - RNAi

(Kumar et al., 2016)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{VDRC.Myd88.U}

Cytology

Nature of the lesion

Statement

Reference

UAS regulatory sequences drive expression of an Myd88 RNAi construct.

(Kumar et al., 2016)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Myd88

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by dlg1^A40.2

(Parisi et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage, with Scer\GAL4^c564

(Kumar et al., 2016)

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Myd88^VDRC.cUa under the control of Scer\GAL4^c564 blocks the normal inflammatory response to Gram-positive bacterial infection (assessed by the expression levels of Drosomycin), but has no significant effect in basal (non-infected) conditions, as compared to controls.

(Kumar et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Myd88^VDRC.cUa, Scer\GAL4^NP6394 is an enhancer of decreased cell number | pupal stage phenotype of Scer\GAL4^NP6394, wek^{UAS.ORF.GW.Tag:HA}

(Foldi et al., 2017)

Myd88^VDRC.cUa/Scer\GAL4^ppl.PP is an enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Myd88^VDRC.cUa/Scer\GAL4^Cg.PA is an enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Myd88^VDRC.cUa/Scer\GAL4^Lsp2.PH is an enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

NOT Enhancer of

Statement

Reference

Myd88^VDRC.cUa/Scer\GAL4^Hml.Δ is a non-enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Other

Statement

Reference

Myd88^VDRC.cUa, Scer\GAL4^ppl.PP, dlg1^A40.2 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Myd88^VDRC.cUa, Scer\GAL4^Cg.PA, dlg1^A40.2 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Myd88^VDRC.cUa, Scer\GAL4^Lsp2.PH, dlg1^A40.2 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Phenotype Manifest In

Enhancer of

Statement

Reference

Myd88^VDRC.cUa, Scer\GAL4^NP6394 is an enhancer of ventral nerve cord | pupal stage phenotype of Scer\GAL4^NP6394, wek^{UAS.ORF.GW.Tag:HA}

(Foldi et al., 2017)

Myd88^VDRC.cUa/Scer\GAL4^ppl.PP is an enhancer of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

Myd88^VDRC.cUa/Scer\GAL4^Cg.PA is an enhancer of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

Myd88^VDRC.cUa/Scer\GAL4^Lsp2.PH is an enhancer of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

NOT Enhancer of

Statement

Reference

Myd88^VDRC.cUa/Scer\GAL4^Hml.Δ is a non-enhancer of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

Other

Statement

Reference

Myd88^VDRC.cUa, Scer\GAL4^ppl.PP, dlg1^A40.2 has wing disc phenotype

(Parisi et al., 2014)

Myd88^VDRC.cUa, Scer\GAL4^Cg.PA, dlg1^A40.2 has wing disc phenotype

(Parisi et al., 2014)

Myd88^VDRC.cUa, Scer\GAL4^Lsp2.PH, dlg1^A40.2 has wing disc phenotype

(Parisi et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The decrease in the number of cells within the Scer\GAL4^Myd88-NP6394 driver's expression domain in the pupal ventral nerve cord (assayed using a nuclear histone-reporter) observed upon expression of wek^{Scer\UAS.ORF.GW.T:Ivir\HA1} is exacerbated further by co-expression of Myd88^VDRC.cUa.

(Foldi et al., 2017)

The apoptosis observed in dlg1^A40.2 mutant wing disc tumors is virtually abrogated by the expression of Myd88^VDRC.cUa under the control of either Scer\GAL4^ppl.PP, Scer\GAL4^Cg.PA or Scer\GAL4^Lsp2.PH.

(Parisi et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Myd88^VDRC.cUa

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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