FlyBase Allele Report: Dmel\brn[UASp.cCa]

General Information

Symbol

Dmel\brn^UASp.cCa

Species

D. melanogaster

Name

FlyBase ID

FBal0325661

Feature type

allele

Associated gene

Dmel\brn

Associated Insertion(s)

Carried in Construct

P{UASp-brn.C}

Also Known As

UAS-Brn

Key Links

Transgenic product class

cDNA

(Chen et al., 2007)

wild_type

(Chen et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Chen et al., 2007)

wild_type

(Chen et al., 2007)

Mutagen

in vitro construct

(Chen et al., 2007)

Progenitor genotype

Carried in construct

P{UASp-brn.C}

Cytology

Description

UASp regulatory sequences drive expression of a full-length brn cDNA.

(Chen et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

brn

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates non-syndromic X-linked intellectual disability 63

modeled by Acsl⁰⁵⁸⁴⁷, Acsl^KO

(Huang et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^nSyb.PS

(Huang et al., 2018)

abnormal neuroanatomy | larval stage, with Scer\GAL4^RapGAP1-OK6

(Huang et al., 2018)

Phenotype Manifest In

embryonic/larval neuromuscular junction, with Scer\GAL4^nSyb.PS

(Huang et al., 2018)

embryonic/larval neuromuscular junction, with Scer\GAL4^RapGAP1-OK6

(Huang et al., 2018)

terminal bouton | larval stage, with Scer\GAL4^nSyb.PS

(Huang et al., 2018)

terminal bouton | larval stage, with Scer\GAL4^RapGAP1-OK6

(Huang et al., 2018)

Detailed Description

Statement

Reference

Expression of brn^UASp.cCa under the control of Scer\GAL4^nSyb.PS or Scer\GAL4^RapGAP1-OK6, but not Scer\GAL4^C57 or Scer\GAL4^repo, significantly reduces bouton number and significantly increases bouton size at the neuromuscular junction of muscle 4, compared to controls, with no effect on the number of satellite boutons.

(Huang et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^nSyb.PS, brn^UASp.cCa has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by wg^{UAS.cHa.Tag:HA}/Scer\GAL4^nSyb.PS

(Huang et al., 2018)

NOT suppressed by