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General Information
Symbol
Dmel\egg2138
Species
D. melanogaster
Name
FlyBase ID
FBal0325693
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C24777670T

Amino acid change:

Q634term | egg-PA

Reported amino acid change:

Q634term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Q634term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

egg2138/Df(2R)Dll-MP and egg2138/Df(2R)ED4065 transheterozygotes are semi-lethal, display a very low male:female ratio, and the rare males die within 2-3 days. egg2138/Df(2R)Dll-MP and egg2138/Df(2R)ED4065 transheterozygous adults exhibit shaky, uncoordinated movements and held-out wings that are incompletely expanded, as compared to controls; these locomotor and wing phenotypes are more pronounced in males than in females.

The generation of egg2138-homozygous germline clone cysts, either in larvae or adults, leads to an apparently normal progression of oogenesis until arrest and apoptosis of stage 5 egg chambers, as compared to controls. Although initially present in the germarium at similar frequency as controls, clonal egg2138 germline stem cells become progressively lost after clone induction; egg2138 follicle stem cell clones are initially less frequent in the ovary as compared to control clones, and also become progressively lost after clone induction.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)