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General Information
Symbol
Dmel\Dsor1E203K.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0325709
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
G9249095A
Amino acid change:
E222K | Dsor1-PA; E219K | Dsor1-PB
Comment:
Analogous mutation in human MEK1 implicated in RAS-related diseases; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change. E203 in human MEK1 aligns with E222 in Drosophila ortholog Dsor1.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASp regulatory sequences drive expression of a constitutively active form of Dsor1.
UASp regulatory sequences drive expression of Dsor1, carrying the activating mutation E203K.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Expression of Dsor1E203K.Scer\UAS.P\T under the combined control of Scer\GAL4nos.UTR.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4otu.T:Hsim\VP16 leads to high embryonic lethality and morphological defects: their cuticles have less than eight segments and the embryos display the pole-hole phenotype.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Dsor1E203K.Scer\UAS.P\T
Dsor1E203K.UASp
Name Synonyms
Secondary FlyBase IDs
    References (2)