FlyBase Allele Report: Dmel\Marf[UAS.cUa]

General Information

Symbol

Dmel\Marf^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0326167

Feature type

allele

Associated gene

Dmel\Marf

Associated Insertion(s)

Carried in Construct

P{UAS-Marf.U}

Also Known As

UAS-Marf

Key Links

Transgenic product class

wild_type

(Altanbyek et al., 2016)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Altanbyek et al., 2016)

Mutagen

in vitro construct

(Altanbyek et al., 2016)

Progenitor genotype

Carried in construct

P{UAS-Marf.U}

Cytology

Description

UAS regulatory sequences drive expression of Marf.

(Altanbyek et al., 2016)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Marf

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis

modeled by Hsap\TAF15^UAS.cCa

(Altanbyek et al., 2016)

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^UAS.cEa

(Altanbyek et al., 2016)

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^UAS.cUa

(Altanbyek et al., 2016)

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 2

modeled by Chchd2^S81L.UAS

(Baek et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^VGlut1-OK371

(Smith et al., 2019)

Phenotype Manifest In

axon | adult stage, with Scer\GAL4^VGlut1-OK371

(Smith et al., 2019)

flight muscle cell | adult stage, with Scer\GAL4^Mef2.247

(Chen et al., 2020)

mitochondrion | adult stage, with Scer\GAL4^Mef2.247

(Chen et al., 2020)

mitochondrion | adult stage, with Scer\GAL4^VGlut1-OK371

(Smith et al., 2019)

Detailed Description

Statement

Reference

Expressing Marf^UAS.cUa under the control of Scer\GAL4^Mef2.247 leads to larger mitochondria in adult flight muscles.

(Chen et al., 2020)

Expression of Marf^UAS.cUa under the control of Scer\GAL4^VGlut-OK371 significantly reduces mitochondrial number in axons of adult neurons, compared to controls, with no effect on mitochondrial length; the number of intact axons in these flies significantly decreases as the flies age, compared to controls.

(Smith et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Marf^UAS.cUa, Scer\GAL4^VGlut1-OK371 has abnormal neuroanatomy | adult stage phenotype, suppressible | partially | somatic clone by gfzf⁵⁴¹

(Smith et al., 2019)

NOT Enhancer of

Statement

Reference

Marf^UAS.cUa/Scer\GAL4^αTub84B.PL is a non-enhancer of lethal - all die during embryonic stage phenotype of gfzf⁵⁴¹

(Smith et al., 2019)

Suppressor of

Statement

Reference

Marf^UAS.cUa/Scer\GAL4^VGlut1-OK371 is a suppressor | partially of abnormal neuroanatomy | somatic clone | adult stage phenotype of gfzf⁵⁴¹

(Smith et al., 2019)

NOT Suppressor of

Statement

Reference

Marf^UAS.cUa/Scer\GAL4^αTub84B.PL is a non-suppressor of lethal - all die during embryonic stage phenotype of gfzf⁵⁴¹

(Smith et al., 2019)

Phenotype Manifest In

Suppressed by

Statement

Reference

Marf^UAS.cUa, Scer\GAL4^VGlut1-OK371 has mitochondrion | adult stage phenotype, suppressible | partially | somatic clone by gfzf⁵⁴¹

(Smith et al., 2019)

Marf^UAS.cUa, Scer\GAL4^VGlut1-OK371 has axon | adult stage phenotype, suppressible | partially | somatic clone by gfzf⁵⁴¹

(Smith et al., 2019)

Enhancer of

Statement

Reference

Marf^UAS.cUa, Scer\GAL4^Mef2.247 is an enhancer of flight muscle cell | adult stage phenotype of Cisd^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Marf^UAS.cUa, Scer\GAL4^Mef2.247 is an enhancer of mitochondrion | adult stage phenotype of Cisd^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Suppressor of

Statement

Reference

Marf^UAS.cUa/Scer\GAL4^VGlut1-OK371 is a suppressor | partially of mitochondrion | somatic clone | adult stage phenotype of gfzf⁵⁴¹

(Smith et al., 2019)

Marf^UAS.cUa/Scer\GAL4^VGlut1-OK371 is a suppressor | partially of axon | somatic clone | adult stage phenotype of gfzf⁵⁴¹

(Smith et al., 2019)

NOT Suppressor of

Statement

Reference

Marf^UAS.cUa, Scer\GAL4^Mef2.247 is a non-suppressor of flight muscle cell | adult stage phenotype of Cisd^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Marf^UAS.cUa, Scer\GAL4^Mef2.247 is a non-suppressor of mitochondrion | adult stage phenotype of Cisd^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Marf^UAS.cUa, Scer\GAL4^Mef2.247 is a non-suppressor of vesicle | adult stage phenotype of Cisd^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

gfzf⁵⁴¹ mutant neural clones partially suppress the reduced mitochondrial number phenotype, but do not suppress the age-related decline in intact axons of adults expressing Marf^UAS.cUa under the control of Scer\GAL4^VGlut-OK371.

(Smith et al., 2019)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Marf^Scer\UAS.cUa

Marf^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

References (8)

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