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General Information
Symbol
Dmel\Mst77FΔ1
Species
D. melanogaster
Name
FlyBase ID
FBal0326352
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

4bp deletion within the Mst77F coding sequence starting at amino acid 10.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

4bp deletion within the Mst77F coding sequence.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mst77FΔ1 homozygotes are male sterile; Mst77FΔ1/Mst77FΔ2, Mst77FΔ1/Mst77FΔ3 and Mst77FΔ1/Df(3L)BSC452 transheterozygous males produce very rare progeny; Mst77FΔ1/Df(3L)BSC452 transheterozygous males and Mst77FΔ1/Df(3L)ri-79c transheterozygous males are fertile but display reduced fertility, as compared to controls.

Mst77FΔ1 homozygous adult males present smaller seminal vesicles, which do not contain mature sperm, as compared to controls; Mst77FΔ1 homozygotes and Mst77FΔ1/Mst77FΔ2 or Mst77FΔ1/Df(3L)BSC452 transheterozygotes present defective spermatid individualization, as compared to controls: spermatids are in disorganized bundles, retain the individualization complexes and present defects in nuclei morphology and chromatin compaction, as compared to controls.

Mst77FΔ1/Mst77FΔ2 and Mst77FΔ1/Df(3L)BSC452 transheterozygotes occasionally present post-individualization spermatid bundles without obvious morphology defects, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
NOT suppressed by
Statement
Reference

Mst77FΔ1 has spermatid cyst | spermatogenesis phenotype, non-suppressible by ProtB[+]/ProtBEGFP

Mst77FΔ1 has cystic bulge | spermatogenesis phenotype, non-suppressible by ProtB[+]/ProtBEGFP

Mst77FΔ1 has nucleus | spermatogenesis phenotype, non-suppressible by ProtB[+]/ProtBEGFP

Mst77FΔ1 has nuclear chromatin | spermatogenesis phenotype, non-suppressible by ProtB[+]/ProtBEGFP

Other
Additional Comments
Genetic Interactions
Statement
Reference

Mst77FΔ1, PBac{PB}Pka-R1c06969 and Mst77FΔ1, Df(2L)ΔMst35B double heterozygous males are fertile, but display a small reduction in fertility as compared to controls.

Mst77FΔ1/+, Df(2L)ΔMst35B/Df(2L)ΔMst35B males exhibit near sterility and defective spermatid individualization, as compared to controls: post-individualization spermatids are in disorganized bundles and exhibit defects in nuclei morphology and chromatin compaction. All these defects are rescued by one copy of Mst77F+tg.

The spermatogenesis defects exhibited by Mst77FΔ1 homozygotes are not enhanced by Df(2L)ΔMst35B heterozygosity or homozygosity, nor suppressed by one copy of ProtBT:Avic\GFP-EGFP.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Not rescued by
Comments

Mst77FΔ1 fails to complement either Mst77FΔ2 or Mst77F[Δ3].

The male sterility of Mst77FΔ1 homozygotes and the male semi-sterility of Mst77FΔ1/Df(3L)BSC452 or Mst77FΔ1/Mst77FΔ2 heterozygotes are partially rescued by one copy of Mst77F+tg; the male semi-sterility observed in Mst77FΔ1/Mst77FΔ2 transheterozygotes is also partially rescued by one copy of Mst77FT:Disc\RFP-mRFP, but not of Mst77FT:Avic\GFP-EGFP.

The spermatogenesis defects observed in Mst77FΔ1 homozygotes are also partially rescued by one copy of Mst77F+tg.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)