FB2025_05 , released December 11, 2025
Allele: Hsap\RELAAD.VT026773
Open Close
General Information
Symbol
Hsap\RELAAD.VT026773
Species
H. sapiens
Name
FlyBase ID
FBal0326484
Feature type
allele
Associated gene
Hsap\RELA
Associated Insertion(s)
Carried in Construct
P{VT026773-p65.AD}
PBac{VT026773-p65.AD}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Aso and Rubin, 2016)
Progenitor genotype
Carried in construct
P{VT026773-p65.AD}
PBac{VT026773-p65.AD}
Cytology
Description

The VT026773 enhancer fragment is fused upstream of the Drosophila synthetic core promoter (DSCP) followed by the p65(AD)::Zip+ hemidriver (component of a 'split driver' system, contains the p65 activation domain).

(Aso and Rubin, 2016)
Allele components
Component
Use(s)
Regulatory region(s)
VT026773
Encoded product / tool
p65(AD)::Zip+
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      mushroom body alpha lobe slice 3

      Comment: when combined with P{R72B05-GAL4.DBD} (combination referred to as 'MB630B')

      (Aso and Rubin, 2016)
      MB-alpha neuron of the dopaminergic PPL1 cluster

      Comment: when combined with P{R72B05-GAL4.DBD} (combination referred to as 'MB630B')

      (Feng et al., 2021)
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Optogenetic activation (using Cnoc\ChR1Cs.IVS.20xUAS.Venus with 627 nm (red) light) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.R72B05 and Hsap\RELAAD.VT026773 in adult females, in combination with a paired odor, results in a long-term aversive olfactory memory for this odor; avoidance is significantly greater when these neurons are not also activated during the testing period.

      Adult females prefer optogenetic activation (using Cnoc\ChR1Cs.IVS.20xUAS.Venus with 627 nm (red) light) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.R72B05 and Hsap\RELAAD.VT026773 to darkness with no activation; this preference is significantly greater than that of controls for red light compared to darkness.

      (Takemura et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (4)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Split-GAL4 transgene, constructed as described in FBrf0212052.

      (Aso and Rubin, 2016)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\RELAAD.VT026773.T:Zzzz\Zip+
      Hsap\RELAAD.VT026773
      Name Synonyms
      Secondary FlyBase IDs
        References (17)