FB2025_01 , released February 20, 2025
Allele: Mmus\Cacfd1UAS.2.Tag:FLAG,Tag:HA
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General Information
Symbol
Mmus\Cacfd1UAS.2.Tag:FLAG,Tag:HA
Species
M. musculus
Name
FlyBase ID
FBal0326653
Feature type
allele
Associated gene
Mmus\Cacfd1
Associated Insertion(s)
Carried in Construct
P{UAS-mFwe.2.FLAG.HA}
Transgenic product class
wild_type
(Yao et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Yao et al., 2017)
Mutagen
in vitro construct
(Yao et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-mFwe.2.FLAG.HA}
Cytology
Description

UAS regulatory sequences drive expression of isoform 2 of Mmus\Cacfd1, that is tagged at the N-terminal end with Tag:FLAG and at the C-terminal end with Tag:HA.

(Yao et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Mmus\Cacfd1
Tagged with
Tag:FLAG
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Mmus\Cacfd1Scer\UAS.2.T:Zzzz\FLAG,T:Ivir\HA1 under the control of Scer\GAL4nSyb.PS rescues the Clathrin-mediated endocytosis defects, the activity-dependent bulk endocytosis defects, and the lowered synaptic vesicle numbers seen in larval neuromuscular junctions of fweDB25/fweDB56 mutants, and also rescues the early larval lethality observed in these mutants.

      (Yao et al., 2017)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mmus\Cacfd1Scer\UAS.2.T:Zzzz\FLAG,T:Ivir\HA1
      Mmus\Cacfd1UAS.2.Tag:FLAG,Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)