FB2025_01 , released February 20, 2025
Allele: Dmel\tauS184A.UAS.RA.Tag:HA
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General Information
Symbol
Dmel\tauS184A.UAS.RA.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0327362
Feature type
allele
Associated gene
Dmel\tau
Associated Insertion(s)
Carried in Construct
PBac{UAS-tau.S184A.RA.HA}
Key Links
Transgenic product class
missense_variant
(Herzmann et al., 2017)
polypeptide_post_translational_processing_variant
(Herzmann et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Herzmann et al., 2017)
polypeptide_post_translational_processing_variant
(Herzmann et al., 2017)
Mutagen
in vitro construct
(Herzmann et al., 2017)
Progenitor genotype
Carried in construct
PBac{UAS-tau.S184A.RA.HA}
Cytology
Description

UASt regulatory sequences drive expression of isoform RA of tau with an amino acid replacement at a par-1 phosphorylation site (S184A), tagged at the C-terminal with Tag:HA.

(Herzmann et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
tau
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of tauS184A.Scer\UAS.RA.T:Ivir\HA1 under the control of Scer\GAL4ppk.PG does not interfere with the dendritic pruning in class IV dendritic arborizing neurons at the pupal stage.

      (Herzmann et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The penetrance of the pruning defects observed in class IV dendritic arborizing neurons of pupae expressing par-1HMS00405 under the control of Scer\GAL4ppk.PG is significantly enhanced by co-expression of tauS184A.Scer\UAS.RA.T:Ivir\HA1.

      (Herzmann et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tauS184A.Scer\UAS.RA.T:Ivir\HA1
      tauS184A.UAS.RA.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)