loss of function allele
Replacement of TCG with CCGA in the Mettl3 coding sequence leads to a frameshift after amino acid 106 and early translation termination.
A frameshift indel in the second exon (coding region) expected to produce a non-functional protein.
flightless (with Df(3R)Exel6197)
visible | adult stage (with Df(3R)Exel6197)
wing (with Df(3R)Exel6197)
Mettl3SK2/Df(3R)Exel6197 adult flies show highly penetrant wing posture defects (held-out wings) and are completely flightless.