loss of function allele
A single base deletion between the ATG of Ythdc1-PB (ATG1) and the second in frame ATG (ATG2) that maps three amino acids downstream of ATG1. ATG2 is retained and translatable. Ythdc1-PA is disrupted.
An early frameshift indel in the coding region of the PA isoform expected to produce a non-functional PA protein. However, the downstream open reading frame of the PB isoform is intact.