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General Information
Symbol
Dmel\axed0011
Species
D. melanogaster
Name
FlyBase ID
FBal0327537
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

16bp deletion in the second coding exon of axed.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

16bp deletion in exon 3 of axed.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies carrying axed0011 mutant somatic clones show defective injury-induced axon degeneration: severed axons (either in sensory neurons in the wing or in cholinergic olfactory receptor neurons) remain intact for a full week after an axotomy (or even 50 days in the latter case), instead of being cleared away. axed0011 MARCM clones of gamma mushroom body neurons do not show any defects in developmental axon or dendrite pruning.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

MARCM clones in sensory neurons in the adult wing expressing Ect4ΔARM.Scer\UAS.T:Hsap\MYC driven by Scer\GAL4VGlut-OK371 undergo spontaneous cell body and axon degeneration which can be suppressed by combination with axed0011.

The axon and cell body degeneration in sensory neuron clones in the adult wing mutant for NmnatΔ4790-1 or expressing NmnatGD8082 under the control of Scer\GAL4VGlut-OK371 can be fully rescued by combination with axed0011.

The NmnatΔ4790-1,axed0011 double mutant clones display defective injury-induced axon degeneration (severed axons remain intact following an axotomy, instead of being cleared away) which cannot be overcome by expressing Ect4ΔARM.Scer\UAS.T:Hsap\MYC under the Scer\GAL4VGlut-OK371 driver in the mutant clones.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Any of the following: axed0011, axedCrisprA, axedCrisprB, axedCrisprC, axedEx07, axedEx65 or axedEx96 fails to complement the lethality of axed0011 mutants, while Ect4896 fails to do so.

The defective injury-induced axon degeneration observed in flies carrying axed0011 mutant neural clones (severed axons in sensory neurons in the adult wing remain intact following an axotomy, instead of being cleared away) can be rescued by clonal Scer\GAL4VGlut-OK371-driven expression of any of the following: axedScer\UAS.long, axedΔBTB.Scer\UAS, axedΔBACK.Scer\UAS, axedΔCterm.Scer\UAS.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (2)