FB2025_01 , released February 20, 2025
Allele: Dmel\Dh44-R2174
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General Information
Symbol
Dmel\Dh44-R2174
Species
D. melanogaster
Name
FlyBase ID
FBal0327572
Feature type
allele
Associated gene
Dmel\Dh44-R2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(King et al., 2017)
Mutagen
CRISPR/Cas9
(King et al., 2017)
Progenitor genotype
Cytology
Description

5bp deletion in exon 6 of Dh44-R2; the frameshift mutation is predicted to result in a non-functional truncated protein with only two transmembrane domains.

(King et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:12,485,131..12,485,135 [+]
Comment:

A 5 bp deletion in the 6th exon of Dh44-R2 leads to a frameshift resulting in a truncated protein.

(King et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dh44-R2174 homozygous adults have similar period length, but significantly reduced strength of circadian locomotor rhythms under constant darkness, compared to heterozygous controls.

      Dh44-R2174/Df(2R)BSC305 adults also have significantly reduced strength of circadian locomotor rhythms under constant darkness, compared to heterozygous controls; there is no difference in their activity profile under light-dark or dark-dark conditions, compared to controls.

      (King et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      Dh44-R2174/Dh44-R2174 is a non-enhancer of abnormal circadian behavior | adult stage phenotype of Dh44-R1DsRed

      (King et al., 2017)
      NOT Suppressor of
      Statement
      Reference

      Dh44-R2174/Dh44-R2174 is a non-suppressor of abnormal circadian behavior | adult stage phenotype of Dh44-R1DsRed

      (King et al., 2017)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Dh44-R2174
      (Li et al., 2020, King et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)