FB2025_05 , released December 11, 2025
Allele: Hsap\RELAAD.R31H10
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General Information
Symbol
Hsap\RELAAD.R31H10
Species
H. sapiens
Name
FlyBase ID
FBal0328716
Feature type
allele
Associated gene
Hsap\RELA
Associated Insertion(s)
Carried in Construct
P{R31H10-p65.AD}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Rubin Laboratory at Janelia Farm, 2017)
Progenitor genotype
Carried in construct
P{R31H10-p65.AD}
Cytology
Description

The GMR31H10 enhancer fragment followed by the Drosophila synthetic core promoter (DSCP) is fused upstream of the p65(AD)::Zip+ hemidriver (component of a 'split driver' system, contains the p65 activation domain).

(Rubin Laboratory at Janelia Farm, 2017)
Allele components
Component
Use(s)
Regulatory region(s)
GMR31H10
Encoded product / tool
p65(AD)::Zip+
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      descending neuron of the anterior dorsal brain DNa07

      Comment: when combined with P{VT040698-GAL4.DBD} (combination referred to as 'SS01560')

      (Namiki et al., 2022, Namiki et al., 2018)
      adult subesophageal zone | restricted

      Comment: when combined with P{R34E03-GAL4.DBD}

      (Hampel et al., 2017)
      dorsal pedicellar campaniform sensillum | subset

      Comment: when combined with P{R34E03-GAL4.DBD}

      (Hampel et al., 2017)
      dorsal scabellar campaniform sensillum | subset

      Comment: when combined with P{R34E03-GAL4.DBD}

      (Hampel et al., 2017)
      mechanosensory neuron of wing margin bristle | subset

      Comment: when combined with P{R34E03-GAL4.DBD}

      (Hampel et al., 2017)
      mechanosensory neuron of interommatidial bristle

      Comment: when combined with P{R34E03-GAL4.DBD}

      (Hampel et al., 2017)
      sensory neuron of campaniform sensillum of distal group | subset

      Comment: when combined with P{R34E03-GAL4.DBD}

      (Hampel et al., 2017)
      sensory neuron of campaniform sensillum of ventral radius | subset

      Comment: when combined with P{R34E03-GAL4.DBD}

      (Hampel et al., 2017)
      adult ventral nerve cord | restricted

      Comment: when combined with P{R34E03-GAL4.DBD}

      (Hampel et al., 2017)
      ventral pedicellar campaniform sensillum | subset

      Comment: when combined with P{R34E03-GAL4.DBD}

      (Hampel et al., 2017)
      ventral scabellar campaniform sensillum | subset

      Comment: when combined with P{R34E03-GAL4.DBD}

      (Hampel et al., 2017)
      descending neuron of the anterior dorsal brain DNa12

      Comment: when combined with P{R22G01-GAL4.DBD} (combination referred to as 'aSP22-SS2')

      (McKellar et al., 2019)
      neuron of adult brain

      Comment: when combined with P{R22G01-GAL4.DBD} (combination referred to as 'aSP22-SS2')

      (McKellar et al., 2019)
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Optogenetic activation (using Cnoc\ChR1Cs.IVS.20xUAS.Venus with red light) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.R34E03 and Hsap\RELAAD.R31H10 elicits prioritised grooming behavior that starts with the eyes and transitions to the wings.

      (Hampel et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\RELAAD.R31H10.T:Zzzz\Zip+
      Hsap\RELAAD.R31H10
      Name Synonyms
      Secondary FlyBase IDs
        References (6)