FB2025_01 , released February 20, 2025
Allele: Hsap\RELAAD.VT026700
Open Close
General Information
Symbol
Hsap\RELAAD.VT026700
Species
H. sapiens
Name
FlyBase ID
FBal0330274
Feature type
allele
Associated gene
Hsap\RELA
Associated Insertion(s)
Carried in Construct
P{VT026700-p65.AD}
Also Known As
VT026700
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Rubin Laboratory at Janelia Farm, 2017)
Progenitor genotype
Carried in construct
P{VT026700-p65.AD}
Cytology
Description

The VT026700 enhancer fragment followed by the Drosophila synthetic core promoter (DSCP) is fused upstream of the p65(AD)::Zip+ hemidriver (component of a 'split driver' system, contains the p65 activation domain).

(Rubin Laboratory at Janelia Farm, 2017)
Allele components
Component
Use(s)
Regulatory region(s)
VT026700
Encoded product / tool
p65(AD)::Zip+
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      third instar larval stage
      larval mushroom body dopaminergic neuron k1

      Comment: when combined with P{VT048348-GAL4.DBD} (combination referred to as 'SS01948')

      (Jovanic et al., 2019)
      larval mushroom body dopaminergic neuron i1

      Comment: when combined with P{VT048348-GAL4.DBD} (combination referred to as 'SS01948')

      when combined with P{VT058464-GAL4.DBD} (combination referred to as 'SS01949')

      (Truman et al., 2023, Jovanic et al., 2019)
      larval mushroom body dopaminergic neuron j1

      Comment: when combined with P{VT048348-GAL4.DBD} (combination referred to as 'SS01948')

      when combined with P{VT058464-GAL4.DBD} (combination referred to as 'SS01949')

      (Truman et al., 2023, Jovanic et al., 2019)
      larval mushroom body dopaminergic neuron h1

      Comment: when combined with P{VT058464-GAL4.DBD} (combination referred to as 'SS01949')

      (Truman et al., 2023)
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using Ctet\TeTxLC[TNT.UAS]) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.VT048348 and Hsap\RELAAD.VT026700 in larvae significantly reduces navigation away from higher wind speeds, compared to controls; movement speed in the absense of wind stimuli is also significantly reduced, compared to controls; turn rate and size of turns are similar to controls; the probability of the first head sweep being away from stronger wind is significantly reduced, compared to controls.

      (Jovanic et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\RELAAD.VT026700.T:Zzzz\Zip+
      Hsap\RELAAD.VT026700
      Name Synonyms
      Secondary FlyBase IDs
        References (4)