FB2025_01 , released February 20, 2025
Allele: Scer\GAL4DBD.VT019911
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General Information
Symbol
Scer\GAL4DBD.VT019911
Species
S. cerevisiae
Name
FlyBase ID
FBal0333586
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{VT019911-GAL4.DBD}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Rubin Laboratory at Janelia Farm, 2017)
Progenitor genotype
Carried in construct
P{VT019911-GAL4.DBD}
Cytology
Description

The VT019911 enhancer fragment followed by the Drosophila synthetic core promoter (DSCP) is fused upstream of the GAL4(DBD)::Zip- hemidriver (component of the 'Split GAL4' system, contains the GAL4 DNA-binding domain).

(Rubin Laboratory at Janelia Farm, 2017)
Allele components
Component
Use(s)
Regulatory region(s)
VT019911
Encoded product / tool
GAL4(DBD)::Zip-
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      wing axillary muscle hg2 motor neuron

      Comment: when combined with P{VT022025-p65.AD} (combination referred to as 'hg2-SG2')

      (O'Sullivan et al., 2018)
      adult neuron | subset of adult metathoracic neuromere | subset

      Comment: when combined with P{VT002851-p65.AD} (combination referred to as 'SS47309')

      (Sterne et al., 2021)
      adult mute subesophageal neuron

      Comment: when combined with P{VT002851-p65.AD} (combination referred to as 'SS47309')

      (Sterne et al., 2021)
      adult neuron | subset of antennal mechanosensory and motor center

      Comment: when combined with P{VT002851-p65.AD} (combination referred to as 'SS47309')

      (Sterne et al., 2021)
      adult neuron | subset of fan-shaped body

      Comment: when combined with P{VT002851-p65.AD} (combination referred to as 'SS47309')

      (Sterne et al., 2021)
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Silencing (using Ctet\TeTxLCTNT.UAS) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.VT019911 and Hsap\RELAAD.VT022025 in adult males significantly alters some parameters of pulse song and sine song, compared to controls; a similar number of males sing and wing extension toward females is unaffected, but copulation success is significantly reduced compared to controls; take off, but not forced flight, ability is significantly impaired compared to controls.

      (O'Sullivan et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Scer\GAL4DBD.VT019911.T:Zzzz\Zip-
      Scer\GAL4DBD.VT019911
      Name Synonyms
      Secondary FlyBase IDs
        References (4)