FB2025_01 , released February 20, 2025
Allele: Dmel\klarKASH.UAS.Tag:HA
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General Information
Symbol
Dmel\klarKASH.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0335707
Feature type
allele
Associated gene
Dmel\klar
Associated Insertion(s)
Carried in Construct
P{UAS-HA.klar.KASH}
Key Links
Transgenic product class
inframe_deletion
(Ding et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Ding et al., 2017)
Mutagen
in vitro construct
(Ding et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-HA.klar.KASH}
Cytology
Description

UASt regulates expression of the KASH domain of klar, tagged at the N-terminus with Tag:HA.

(Ding et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
klar
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of klarScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Mef2.247 leads to significant defects in myonuclear spacing (i.e. nuclear clustering) in third instar larval muscle fibers, as compared to controls. Clonal expression under the control of Scer\GAL4Scer\FRT.Rnor\Cd2.Act5C, however, does not lead to significant changes in apoptosis or in cell area in the follicular epithelium, as compared to controls.

      (Ding et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The expression of klarScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Scer\FRT.Rnor\Cd2.Act5C enhances the increased apoptosis observed in kudKO homozygous follicular epithelium clones.

      (Ding et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      klarKASH.UAS.Tag:HA
      klarScer\UAS.T:Ivir\HA1
      klarUAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)