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General Information
Symbol
Dmel\Ptp69DCRISPR.14
Species
D. melanogaster
Name
FlyBase ID
FBal0336316
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

An 8 bp deletion causes a frameshift after Q115. In addition, 14 bp downstream of the deletion, the sequence AATTCC is replaced with TATCCA.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Frame-shifting mutation i the first extracellular Ig domain: 8bp deletion starting in codon 116 plus insertion of TATCCA in place of the sequence AATTCC normally found at codons 123 and 124.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

MARCM clones for Ptp69DCRISPR.14 in class IV dendritic arborizing neurons in third instar larvae show strong reduction in terminal dendrite density (but not total dendrite density or terminal dendrite number) compared to controls. Ptp69DCRISPR.14/Df(3L)8ex34 transheterozygous larvae display severe decrease in both the total and terminal dendrite density as well as terminal dendrite number.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The decreased terminal dendrite density and number in class IV dendritic arborizing neurons observed in third instar larvae either expressing sotvGD2025 (with the Scer\GAL4A58 driver) or transheterozygous for Ptp69DCRISPR.14/Df(3L)8ex34 is further enhanced in the double mutants (Scer\GAL4A58>sotvGD2025;Ptp69DCRISPR.14/Df(3L)8ex34).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The strong decrease in the total and terminal dendrite density as well as terminal dendrite number observed in class IV dendrite arborizing neurons in Ptp69DCRISPR.14/Df(3L)8ex34 third instar larvae is fully rescued by expression of either Ptp69DScer\UAS.T:Hsap\MYC or Ptp69DΔIg.Scer\UAS under the control of Scer\GAL4ppk.PU in the mutant background.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Ptp69DCRISPR.14
Name Synonyms
Secondary FlyBase IDs
    References (1)