FB2025_01 , released February 20, 2025
Allele: Dmel\Spn77BcSK4
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General Information
Symbol
Dmel\Spn77BcSK4
Species
D. melanogaster
Name
FlyBase ID
FBal0336444
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

A frameshift allele that truncates the majority of the coding potential of the gene.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Comment:

A 1 bp deletion in the Spn77Bc coding region leads to a frameshift. There is also a two base substitution (TT/GA) just upstream of the deletion.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Spn77BcSK4 mutant adults do not show any overt morphological defects. However, adult males carrying the Spn77BcSK4 allele over a cognate deficiency as well as Spn77BcSK4 homozygotes do not display any decrease in male fecundity, despite the significant increase in the frequency of spermatid individualization defects and high proportion of abnormal individualization complexes, the deposition of mature sperm to the seminal vesicles is also compromised.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Spn77BcSK4
Name Synonyms
Secondary FlyBase IDs
    References (1)