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General Information
Symbol
Dmel\cnk63F
Species
D. melanogaster
Name
FlyBase ID
FBal0336631
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G17419419A

Amino acid change:

W17term | cnk-PA; W17term | cnk-PB

Reported amino acid change:

W17term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: W17term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

cnk63F/Df(2R)BSC161 embryos derived from mothers bearing cnk63F mutant germline clones and thus lacking both maternal and zygotic cnk show a complete loss of muscle founder cells at late embryonic stages. The embryos also display mild defects in the formation of ectodermal and endodermal derivatives of the alimentary tract (hindgut and Malpighian tubules are shortened) as well as severe heart and dorsal muscle formation defects, absence of eve-positive pericardial cells, impaired longitudinal visceral muscle migration, abnormal muscle attachment sites and impaired tracheal development.

cnk63F;cnkfTRG1248 rescue flies survive to adulthood but display rough eye phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The reduced pupal size characteristic for animals expressing jebScer\UAS.cVa under the control of Scer\GAL4elav-C155 is partially suppressed by combination with a single copy of cnk63F.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)