FB2025_01 , released February 20, 2025
Allele: Dmel\cnkΔY2H
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General Information
Symbol
Dmel\cnkΔY2H
Species
D. melanogaster
Name
FlyBase ID
FBal0336636
Feature type
allele
Associated gene
Dmel\cnk
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Wolfstetter et al., 2017)
Mutagen
CRISPR/Cas9
(Wolfstetter et al., 2017)
Progenitor genotype
Cytology
Description

Deletion removing sequence encoding cnk amino acids 1182-1538.

(Wolfstetter et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:17,414,633..17,415,703 [-]
Comment:

The deletion removes amino acids 1182-1538 and maps to 2R:17414633..17415703 .

(Wolfstetter and Palmer, 2018.2.5)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cnkΔY2H/Df(2R)BSC161 embryos derived from mothers bearing cnkΔY2H mutant germline clones and thus lacking both maternal and zygotic cnk do not show any apparent defects in the morphology of either fore- or hindgut and their Malpighian tubules are elongated normally but are often displaced and the embryos exhibit only mild defects in the formation of heart, visceral longitudinal or dorsal somatic muscles, muscle attachment sites or tracheae.

      cnkΔY2H as well as cnkΔY2H/cnk63F mutant adults display a rough eye phenotype.

      (Wolfstetter et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      cnkΔY2H
      (Wolfstetter et al., 2020, Wolfstetter et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)