FB2025_01 , released February 20, 2025
Allele: Dmel\aveCC9-36B
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General Information
Symbol
Dmel\aveCC9-36B
Species
D. melanogaster
Name
FlyBase ID
FBal0336642
Feature type
allele
Associated gene
Dmel\ave
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Wolfstetter et al., 2017)
Progenitor genotype
Cytology
Description

103bp deletion, including the ave translation start codon, plus insertion of 8bp.

(Wolfstetter et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:14,752,530..14,752,632 [+]
Comment:

103 bp in ave including the translation start have been deleted and eight nucleotides (AAACTACG) have been inserted at the site of the deletion.

Inserted_sequence:

AAACTACG

(Wolfstetter et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  cancer
      modeled by AlkUAS.cLa
      (Wolfstetter et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      aveCC9-36B/aveCC9-20A embryos derived from mothers bearing aveCC9-36B mutant germline clones and thus lacking both maternal and zygotic ave show a complete loss of muscle founder cells, scattering of the visceral mesoderm after germband retraction and absence of functional gut musculature at late embryonic stages.

      (Wolfstetter et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      aveCC9-36B
      (Wolfstetter et al., 2020, Wolfstetter et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)