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General Information
Symbol
Dmel\GlosGD17786
Species
D. melanogaster
Name
FlyBase ID
FBal0336670
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS.Glos-IRDEX, Glos RNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulates expression of an dsRNA construct targeting Glos for RNAi-mediated degradation.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of GlosGD17786 under the control of Scer\GAL4Mef2.PR has no effect on flight ability of adult flies, mobility of the third instar larvae or shape of pupae and Scer\GAL4elav-C155-driven expression does not impair adult viability.

Expression of GlosGD17786, together with UAS-Dicer2 to enhance RNAi efficiency, is lethal at both 25[o]C or 29[o]C if driven by Scer\GAL4αTub84B.PL, Scer\GAL4da.G32, Scer\GAL4how-24B or Scer\GAL4c179 and at 25[o]C only if driven by Scer\GAL4insc-Mz1407 (but only partially lethal at 29[o]C). Adult viability is not significantly reduced if GlosGD17786 is controlled by Scer\GAL4RapGAP1-OK6, Scer\GAL4elav-C155, Scer\GAL4G7 or Scer\GAL4Mef2.PR. Scer\GAL4αTub84B.PL-, Scer\GAL4da.G32- or Scer\GAL4c179-driven expression is lethal at both temperatures (and at just 29[o]C with Scer\GAL4how-24B) even without the UAS-Dicer2.

The climbing (especially at late adulthood) as well as the flight ability of flies expressing GlosGD17786 (with UAS-Dicer2) under the control of either Scer\GAL4Mef2.PR or Scer\GAL4elav-C155 is strongly reduced and the adult survival rate is also significantly decreased with the Scer\GAL4elav-C155 driver.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Gem3ΔN.Scer\UAS together with GlosGD17786 are adult lethal and leads to strongly reduced mobility in third instar larvae and more elongated shape of the puparium with the Scer\GAL4Mef2.PR driver and to reduced viability with Scer\GAL4elav-C155.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
GlosGD17786
Name Synonyms
Secondary FlyBase IDs
    References (2)