FB2025_02 , released April 17, 2025
Allele: Dmel\ttkUAS.Tag:FLAG
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General Information
Symbol
Dmel\ttkUAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0337775
Feature type
allele
Associated gene
Dmel\ttk
Associated Insertion(s)
Carried in Construct
P{UAS-ttk.FLAG}
Key Links
Transgenic product class
cDNA
(Yin and Xi, 2018)
wild_type
(Yin and Xi, 2018)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Yin and Xi, 2018)
wild_type
(Yin and Xi, 2018)
Mutagen
in vitro construct
(Yin and Xi, 2018)
Progenitor genotype
Carried in construct
P{UAS-ttk.FLAG}
Cytology
Description

UAS regulatory sequences drive expression of ttk cDNA, tagged with 3xTag:FLAG.

(Yin and Xi, 2018)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ttk
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adulthood-only expression of ttkScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4esg-NP5130 (using Gal80[ts] for the temporal control of expression) leads to no significant effect in the number of enteroendocrine cells in the adult midgut, as compared to controls.

      Clonal expression of ttkScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Act.PU in the adult midgut results in very small clones, many remaining as single or double cell clones.

      (Yin and Xi, 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The severely increased number of enteroendocrine cells in the adult midgut resulting from the adulthood-only expression of phylScer\UAS.cPa under the control of Scer\GAL4esg-NP5130 (using Gal80[ts]) is suppressed by the co-expression of ttkScer\UAS.T:Zzzz\FLAG.

      The small size and cell number of adult midgut clones expressing scScer\UAS.cPa under the control of Scer\GAL4Act.PU is partially suppressed by the co-expression of phylScer\UAS.cPa.

      (Yin and Xi, 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ttkScer\UAS.T:Zzzz\FLAG
      ttkUAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (1)