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General Information
Symbol
Dmel\ash1AM1
Species
D. melanogaster
Name
FlyBase ID
FBal0338137
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

A 233 bp deletion resulting in a frameshift at amino acid N312 (originally reported as N303 based on an outdated version of the ash1 annotation).

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of nucleotides 907-1139, resulting in a frameshift a amino acid residue N303.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ash1N303mut is a dominant enhancer of eye pigment variegation observed in the E1 (combination of gypsy{}ci-E1, P{lacW}Dplac) and Pci (P{lacW}Dplac) backgrounds; no eye pigmentation silencing is observed in a P{lacW}3-76a background.

ash1N303mut is a significant dominant suppressor of eye pigment variegation observed in the In(1)w[m4] background.

The following transheterozygotes are lethal: ash1N303mut/Df(3L)Exel9007, ash1N303mut/ash1W790term, ash1N303mut/ash1Q893term, ash1N303mut/ash1H1873W and ash1N303mut/ash1W770mut.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Enhancer of
Statement
Reference
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

ash1N303mut/+, trxS2582a/+ and ash1N303mut/+, trxS2582b/+ double heterozygotes are viable, whereas ash1N303mut/+, trxR1578mut/+ double heterozygotes are semi-viable, as compared to controls.

ash1N303mut/+, trxS2582a/+ double heterozygous females show a dominant enhancer of eye pigment variegation phenotype which is more severe than either single heterozygote.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
ash1AM1
ash1N303mut
Name Synonyms
Secondary FlyBase IDs
    References (2)