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General Information
Symbol
Hsap\APOL1G1.UAS.cFa
Species
H. sapiens
Name
UAS construct a of Fu
FlyBase ID
FBal0342167
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulates expression of the G1 Hsap\APOL1 allele, which differs from the wild type APOL1-G0 only at S342 and I384, obtained from a cDNA library generated from podocytes cultured from a child with HIV-associated nephropathy.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Expressing Hsap\APOL1G1.UAS.cFa under the control of Scer\GAL4Mef2.PR leads to some individuals showing a 'held-out wing' phenotype and to disorganized and reduced indirect flight muscle fibers; Scer\GAL4Bx-MS1096-driven expression induces smaller and misshapen wings, plus vein abnormalities; Scer\GAL4vg.PU-driven expression induces wing vein defects. Although adult pericardial nephrocytes expressing Hsap\APOL1G1.UAS.cFa under the control of Scer\GAL4Ugt36A1.PK start by exhibiting higher uptake function at day 1, there is a progressive decrease in function at days 8 and 15, as compared to controls; despite being of similar sizes to controls at day 1, these nephrocytes progressively increase in size (at days 8 and 15), as compared to controls.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Hsap\APOL1G1.UAS.cFa
Name Synonyms
UAS construct a of Fu
Secondary FlyBase IDs
    References (1)