UASt regulates expression of the G1 haplotype of the Hsap\APOL1 gene, comprises two nonsynonymous coding variants rs73885319 (S342G) and rs60910145 (I384M) within the C-terminal Serum Resistance-Associated (SRA) interacting domain. This variant is associated with a markedly increased risk of progressive kidney disease in sub-Saharan African ancestry populations.
Expressing Hsap\APOL1G1.UAS.cKa under the control of Scer\GAL4da.PU induces almost full lethality; one individual that succeeded in eclosing displays a severe wing phenotype.
Scer\GAL4GMR.PU-driven expression induces a very frequent and severe 'rough eye' phenotype, with a concave structure and disrupted ommatidial structure.
Adult pericardial nephrocytes expressing Hsap\APOL1G1.UAS.cKa under the control of Scer\GAL4Ugt36A1.PK exhibit increased uptake function, as compared to controls.