FB2025_01 , released February 20, 2025
Allele: Dmel\Cpsf5H11
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General Information
Symbol
Dmel\Cpsf5H11
Species
D. melanogaster
Name
FlyBase ID
FBal0342908
Feature type
allele
Associated gene
Dmel\Cpsf5
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Tang et al., 2018)
Progenitor genotype
Cytology
Description

13bp deletion leads to a frame shift and a potential 36aa peptide.

(Tang et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3L:9,411,308..9,411,321 [+]
Comment:

CTCCGGTTGGCCGC is deleted and replaced with a T just downstream of the Cpsf5 ATG for a net deletion of 13 bases. This leads to a frameshift and early translation termination.

Inserted_sequence:

T

(Tang et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cpsf5H11 larval fat body clones show impaired induction of autophagosomes (identified as mCherry-Atg8 puncta) in response to starvation.

      (Tang et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CPSF5H11
      (Tang et al., 2018)
      Cpsf5H11
      Name Synonyms
      Secondary FlyBase IDs
        References (1)