Genomic fragment containing the Atx2 locus. Sequence encoding Atx2 amino acid residues 420-440 (prion-like domain) and 548-656 (endogenous polyQ repeats) have been deleted. The deleted sequence comprises the internal intrinsically disordered region.
memory defective | adult stage, with Atx2X1/Atx206490
Adult Atx2X1/Atx206490 transheterozygotes bearing Atx2ΔmIDR exhibit significantly lower long-term olfactory habituation, as compared to controls.
Atx2ΔmIDR rescues Atx2X1/Atx206490
Atx2ΔmIDR rescues Atx2X1
Atx2ΔmIDR rescues the lethality of Atx2X1/Atx206490 and the dendrite targeting defects of Atx2X1 adult antennal lobe projection neuron clones.