FlyBase Allele Report: Hsap\HOXA9::Hsap\NUP98[WT.UAS]

General Information

Symbol

Hsap\HOXA9::Hsap\NUP98^WT.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0343909

Feature type

allele

Associated gene

Hsap\HOXA9::Hsap\NUP98

Associated Insertion(s)

Carried in Construct

P{UAS-hNA9.WT}

Also Known As

UAS-NA9

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Baril et al., 2017)

Progenitor genotype

Carried in construct

P{UAS-hNA9.WT}

Cytology

Description

UASt regulates expression of the 'wild type' form of the "NUP98-HOXA9" (NA9) translocation, which fuses the amino-terminal part of human NUP98 to the carboxyl-terminal part (DNA binding domain) of human HOXA9, and causes Acute myeloid leukemia (AML).

(Baril et al., 2017)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\HOXA9::Hsap\NUP98

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of acute myeloid leukemia

CEA

(Gavory et al., 2021, Baril et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of acute myeloid leukemia

is exacerbated by Pvr^GD14375

(Baril et al., 2017)

is ameliorated by Pvr^UAS.cDa

(Baril et al., 2017)

is exacerbated by hth^UAS.cPa

(Baril et al., 2017)

is exacerbated by gpp^HMS00160

(Gavory et al., 2021)

is ameliorated by grh^JF02305

(Gavory et al., 2021)

is exacerbated by CG6583^E-1012

(Gavory et al., 2021)

is exacerbated by CG6583^GD1099

(Gavory et al., 2021)

is ameliorated by grh^S-159

(Gavory et al., 2021)

is exacerbated by E(Pc)^NIG.7776R

(Gavory et al., 2021)

is exacerbated by HDAC1^GL01005

(Gavory et al., 2021)

is ameliorated by hth^NIG.17117R

(Gavory et al., 2021)

is ameliorated by HDAC1^UAS.Tag:V5

(Gavory et al., 2021)

is exacerbated by hth^UAS.GFP

(Gavory et al., 2021)

is exacerbated by Rae1^E-992

(Gavory et al., 2021)

is exacerbated by Rae1^GD14705

(Gavory et al., 2021)

is exacerbated by nej³

(Gavory et al., 2021)

is exacerbated by Tip60^HM05049

(Gavory et al., 2021)

is exacerbated by dom^HMS02162

(Gavory et al., 2021)

is ameliorated by nej^UAS.Tag:V5

(Gavory et al., 2021)

is ameliorated by eIF3b^S-1820

(Gavory et al., 2021)

is ameliorated by eIF3b^S-2265

(Gavory et al., 2021)

is exacerbated by shot^JF02971

(Gavory et al., 2021)

is ameliorated by eIF3b^S-4212

(Gavory et al., 2021)

is exacerbated by ed^KK106928

(Gavory et al., 2021)

is exacerbated by emb^KK102552

(Gavory et al., 2021)

is ameliorated by stan^KK100512

(Gavory et al., 2021)

is ameliorated by exd^KK107300

(Gavory et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Baril et al., 2017)

NUP98/HOXA9_fusion

(FlyBase curators, 2019-)

Variants Synonym(s)

t(7;11)(p15;p15) NUP98/HOXA9

Associated human disease model(s)

acute myeloid leukemia, NUP98-HOXA9 fusion

External database links

Comments concerning this variant

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult cuticle, with Scer\GAL4^ey.PH

(Gavory et al., 2021)

adult head, with Scer\GAL4^ey.PH

(Gavory et al., 2021)

embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4^Hml.Δ

(Baril et al., 2017)

embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4^Hml.Δ

(Baril et al., 2017)

embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4^Pxn.PS

(Baril et al., 2017)

eye, with Scer\GAL4^ey.PH

(Gavory et al., 2021)

eye disc | third instar larval stage, with Scer\GAL4^ey.PH

(Gavory et al., 2021)

eye disc morphogenetic furrow | third instar larval stage, with Scer\GAL4^ey.PH

(Gavory et al., 2021)

lamellocyte | third instar larval stage, with Scer\GAL4^Hml.Δ

(Baril et al., 2017)

medullary zone of lymph gland primary lobe | third instar larval stage, with Scer\GAL4^Hml.Δ

(Baril et al., 2017)

posterior signaling center of lymph gland primary lobe | third instar larval stage, with Scer\GAL4^Hml.Δ

(Baril et al., 2017)

posterior signaling center of lymph gland primary lobe | third instar larval stage, with Scer\GAL4^{kn-col85-GAL4}

(Baril et al., 2017)

posterior signaling center of lymph gland primary lobe | third instar larval stage, with Scer\GAL4^Pxn.PS

(Baril et al., 2017)

primary lobe of embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4^Hml.Δ

(Baril et al., 2017)

secondary lobe of embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Detailed Description

Statement

Reference

The expression of Hsap\HOXA9::Hsap\NUP98^WT.UAS under the control of Scer\GAL4^ey.PH leads to a small eye phenotype, with an associated expansion of the anterior dorsal and ventral head cuticles; in agreement, third instar eye discs are smaller, with delayed morphogenetic furrow progression in the dorsal compartment and smaller differentiating zone.

(Gavory et al., 2021)

Larvae expressing Hsap\HOXA9::Hsap\NUP98^WT.UAS under the control of Scer\GAL4^Hml.Δ show a fully penetrant lymph gland enlargement, where most individuals show dispersion of the primary lobe accompanied by enlargement of the secondary lobe and a few individuals showing primary lobe enlargement, as compared to controls. These larval lymph glands show increased mitotic index (phospho-H3 staining) and a severe increase in the numbers of Hml-positive lymph gland cells; this correlates with a severe increase in the number of Hml-positive circulating hemocytes, which show a similar ability to phagocyte E.coli and S.aureus as controls, although the proportion of circulating P1-positive hemocytes seems decreased. The medullary zone of non-dispersed lymph glands is smaller than controls, but there are no apparent changes in terminal differentiation into plasmocytes (P1-positive cells) or crystal cells (Hnt-positive cells), as compared to controls. The posterior signalling center is larger, with more total and mitotic cells, as compared to controls.

Depending on the Hsap\HOXA9::Hsap\NUP98^WT.UAS insertion (and corresponding inducible expression levels), Scer\GAL4^Hml.Δ-driven expression induces lamellocyte differentiation in the lymph gland.

Expression under the control of Scer\GAL4^Pxn.PS also results in an enlarged larval lymph gland, with a severely enlarged and misshapen posterior signalling center. Expression under the control of Scer\GAL4^{kn-col85-GAL4} also induces a severely enlarged posterior signalling center.

Expression under the control of either Scer\GAL4^ey.PH or Scer\GAL4^Bx-MS1096 does not induce overgrowth in the eye disc or wing disc, respectively.

(Baril et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, enhanceable by ed^KK106928, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has increased size | adult stage phenotype, enhanceable by ed^KK106928, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, enhanceable by gpp^HMS00160, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has increased size | adult stage phenotype, enhanceable by gpp^HMS00160, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, enhanceable by Rae1^GD14705, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, enhanceable by shot^JF02971, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has increased size | adult stage phenotype, enhanceable by shot^JF02971, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, enhanceable by E(Pc)^NIG.7776R, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has increased size | adult stage phenotype, enhanceable by E(Pc)^NIG.7776R, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has increased size | adult stage phenotype, enhanceable by CG6583^GD1099, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has decreased size | adult stage phenotype, enhanceable by nej[+]/nej³

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, enhanceable by nej[+]/nej³

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, enhanceable by nej[+]/nej^P

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has decreased size | adult stage phenotype, enhanceable by nej[+]/nej^P

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, enhanceable by nej[+]/nej^G0350

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has decreased size | adult stage phenotype, enhanceable by nej[+]/nej^G0350

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has decreased size | adult stage phenotype, enhanceable by HDAC1^UAS.Tag:V5, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, enhanceable by HDAC1^UAS.Tag:V5, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, enhanceable by emb^KK102552, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by hth^UAS.cPa, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by Pvr^GD14375, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has abnormal size | third instar larval stage phenotype, enhanceable by Pvr^GD14375, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Suppressed by

Statement

Reference

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, suppressible by exd^KK107300, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has abnormal size | adult stage phenotype, suppressible by exd^KK107300, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, suppressible | partially by hth^NIG.17117R, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has abnormal size | adult stage phenotype, suppressible | partially by hth^NIG.17117R, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Act5C.PP, hth^UAS.GFP has neoplasia | adult stage | somatic clone - tissue specific phenotype, suppressible by exd^KK107300, Scer\GAL4^Act5C.PP

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has decreased size | adult stage phenotype, suppressible | partially by grh^JF02305, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, suppressible | partially by stan^KK100512, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has decreased size | adult stage phenotype, suppressible | partially by stan^KK100512, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, suppressible | partially by grh^JF02305, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, suppressible | partially by nej^UAS.Tag:V5, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has abnormal size | adult stage phenotype, suppressible | partially by nej^UAS.Tag:V5, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has abnormal size | adult stage phenotype, suppressible | partially by HDAC1^GL01005, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, suppressible | partially by HDAC1^GL01005, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible by Pvr^UAS.cDa, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has abnormal size | third instar larval stage phenotype, suppressible by Pvr^UAS.cDa, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

NOT suppressed by

Statement

Reference

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, non-suppressible by hth^KK108831, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, non-suppressible by exd^GD1439, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, non-suppressible by hth^KK108831/exd^GD1439, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

NOT Suppressor of

Statement

Reference

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Act5C.PP is a non-suppressor of decreased size | adult stage | somatic clone - tissue specific phenotype of Scer\GAL4^Act5C.PP, hth^UAS.GFP

(Gavory et al., 2021)

Other

Statement

Reference

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH, dom^HMS02162 has visible | adult stage phenotype

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH, dom^HMS02162 has abnormal size | adult stage phenotype

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Act5C.PP, hth^UAS.GFP has neoplasia | adult stage | somatic clone - tissue specific phenotype

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH, Tip60^HM05049 has visible | adult stage phenotype

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH, Tip60^HM05049 has abnormal size | adult stage phenotype

(Gavory et al., 2021)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has adult cuticle phenotype, enhanceable by ed^KK106928, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has adult head phenotype, enhanceable by ed^KK106928, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, enhanceable by gpp^HMS00160, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has adult cuticle phenotype, enhanceable by gpp^HMS00160, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has adult head phenotype, enhanceable by gpp^HMS00160, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, enhanceable by Rae1^GD14705, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, enhanceable by shot^JF02971, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has adult cuticle phenotype, enhanceable by shot^JF02971, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has adult head phenotype, enhanceable by shot^JF02971, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, enhanceable by E(Pc)^NIG.7776R, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has adult cuticle phenotype, enhanceable by E(Pc)^NIG.7776R, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has adult head phenotype, enhanceable by E(Pc)^NIG.7776R, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, enhanceable by CG6583^GD1099, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has adult cuticle phenotype, enhanceable by CG6583^GD1099, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has adult head phenotype, enhanceable by CG6583^GD1099, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, enhanceable by nej[+]/nej³

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, enhanceable by nej[+]/nej^P

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, enhanceable by nej[+]/nej^G0350

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, enhanceable by HDAC1^UAS.Tag:V5, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, enhanceable by emb^KK102552, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, enhanceable by ed^KK106928, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has embryonic/larval lymph gland | third instar larval stage phenotype, enhanceable by hth^UAS.cPa, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by hth^UAS.cPa, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has embryonic/larval lymph gland | third instar larval stage phenotype, enhanceable by Pvr^GD14375, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by Pvr^GD14375, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Suppressed by

Statement

Reference

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, suppressible by exd^KK107300, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, suppressible | partially by hth^NIG.17117R, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Act5C.PP, hth^UAS.GFP has adult cuticle | somatic clone - tissue specific phenotype, suppressible by exd^KK107300, Scer\GAL4^Act5C.PP

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Act5C.PP, hth^UAS.GFP has adult head | somatic clone - tissue specific phenotype, suppressible by exd^KK107300, Scer\GAL4^Act5C.PP

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, suppressible | partially by grh^JF02305, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, suppressible | partially by nej^UAS.Tag:V5, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has eye phenotype, suppressible | partially by HDAC1^GL01005, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has embryonic/larval lymph gland | third instar larval stage phenotype, suppressible by Pvr^UAS.cDa, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible by Pvr^UAS.cDa, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has posterior signaling center of lymph gland primary lobe | third instar larval stage phenotype, suppressible by Pvr^UAS.cDa, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

NOT suppressed by

Statement

Reference

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has embryonic/larval lymph gland | third instar larval stage phenotype, non-suppressible by hth^KK108831, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, non-suppressible by hth^KK108831, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has embryonic/larval lymph gland | third instar larval stage phenotype, non-suppressible by exd^GD1439, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, non-suppressible by exd^GD1439, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has embryonic/larval lymph gland | third instar larval stage phenotype, non-suppressible by hth^KK108831/exd^GD1439, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, non-suppressible by hth^KK108831/exd^GD1439, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

NOT Suppressor of

Statement

Reference

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Act5C.PP is a non-suppressor of eye | adult stage | somatic clone - tissue specific phenotype of Scer\GAL4^Act5C.PP, hth^UAS.GFP

(Gavory et al., 2021)

Other

Statement

Reference

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH, dom^HMS02162 has wing | ectopic phenotype

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH, nej[+]/nej^P has wing | ectopic phenotype

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH, nej[+]/nej^G0350 has wing | ectopic phenotype

(Gavory et al., 2021)

E(Pc)^NIG.7776R, Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has wing | ectopic phenotype

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Act5C.PP, hth^UAS.GFP has adult head | somatic clone - tissue specific phenotype

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Act5C.PP, hth^UAS.GFP has adult cuticle | somatic clone - tissue specific phenotype

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH, Tip60^HM05049 has wing | ectopic phenotype

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH, nej[+]/nej³ has wing | ectopic phenotype

(Gavory et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

The induction of eye-specific clones (induced by ey-FLP) that co-express hth^UAS.GFP and Hsap\HOXA9::Hsap\NUP98^WT.UAS under the control of Scer\GAL4^Act5C.PP leads to large cuticular overgrowths in the posterior region of adult eyes.

The co-expression of Hsap\HOXA9::Hsap\NUP98^WT.UAS with E(Pc)^NIG.7776R, dom^HMS02162, or Tip60^HM05049 under the control of Scer\GAL4^ey.PH leads to ectopic wing-like structures in the dorsal-anterior part of the eye. Likewise, nej^P/+, nej³/+ or nej^G0350/+ adults expressing Hsap\HOXA9::Hsap\NUP98^WT.UAS under the control of Scer\GAL4^ey.PH show ectopic wing-like structures in the dorsal-anterior part of the eye.

(Gavory et al., 2021)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

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Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\HOXA9::Hsap\NUP98^WT.UAS

Hsap\NA9^WT.UAS

Name Synonyms

Secondary FlyBase IDs

References (3)

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