FB2025_01 , released February 20, 2025
Allele: Dmel\oskΔNLS.A
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General Information
Symbol
Dmel\oskΔNLS.A
Species
D. melanogaster
Name
FlyBase ID
FBal0343924
Feature type
allele
Associated gene
Dmel\osk
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Kistler et al., 2018)
Mutagen
CRISPR/Cas9
(Kistler et al., 2018)
gene targeting by homologous recombination
(Kistler et al., 2018)
Progenitor genotype
Cytology
Description

The NLS1 (putative nuclear localization sequence within L1) region is deleted from the endogenous osk locus.

(Kistler et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:8,936,186..8,936,212 [+]
Inserted_sequence:

TGTCCC

Comment:

The NLS1 (putative nuclear localization sequence within L1) region is deleted from the endogenous osk locus. The indicated sequence has been deleted and a six base sequence (TGTCCC) remains at the site of the deletion.

(Kistler et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      oskΔNLS.A/oskΔNLS.B transheterozygous embryos show a significant decrease in the number of PGCs, but no change in the number of PGC buds, as compared to heterozygous controls; there are no significant differences in hatching rate.

      (Kistler et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      OskΔNLS-A
      (Kistler et al., 2018)
      OskΔNLS-alleleA
      (Kistler et al., 2018)
      oskΔNLS.A
      Name Synonyms
      Secondary FlyBase IDs
        References (1)