Open Close
General Information
Symbol
Dmel\PAPLA11
Species
D. melanogaster
Name
FlyBase ID
FBal0344002
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

A 5,643bp deletion that removes most of of the PAPLA1 coding sequence. A 6bp deletion in PAPLA1 is also present in this allele.

deletion
Comment:

A 6bp deletion that in the PAPLA1 coding sequence. A 5,643bp deletion in PAPLA1 is also present in this allele. The deletion is reported to map to 2L:8140673..8140678 , R6 coordinates.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The second deletion in PAPLA1[1] has coordinates 2L:8140324..8134682 .

6bp deletion (coordinates 2L:8140678..8140673 , release 6 genome) plus 5643bp deletion with two additional nucleotides (AT) in between the deletion breakpoints. This removes much of the PAPLA1 coding sequence.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

PAPLA11 mutants are semi-lethal and show a delay to pupariation, but do not show differences in body size (assessed by pupal volume and adult wing size); adults show significant decreases in food intake an din spontaneous activity, as compared to controls. Mutant females have smaller ovaries, which show increased egg chamber degeneration at mid-oogenesis and occasional persistence of nurse cell nuclei after stage 13 of oogenesis, but no other obvious morphology defects, as compared to controls; their mating to control males leads to significantly fewer eggs being laid, which hatch at a slightly but significantly lower rate, as compared to controls. Mutant males show smaller reproductive organs (i.e. testes and accessory glands) and their mating to control females leads to decreased egg laying and egg hatch rate, as compared to control males.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (2)