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General Information
Symbol
Dmel\Hrb27CJ6
Species
D. melanogaster
Name
FlyBase ID
FBal0344046
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C6924928T

Amino acid change:

Q247term | Hrb27C-PA; Q247term | Hrb27C-PB; Q247term | Hrb27C-PC; Q247term | Hrb27C-PD; Q247term | Hrb27C-PE; Q247term | Hrb27C-PF; Q247term | Hrb27C-PG; Q247term | Hrb27C-PH

Reported amino acid change:

Q247term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Q247term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hrb27CJ6/Hrb27CJ6 and Hrb27CJ6/Df(2L)BSC108 animals have small imaginal discs compared to heterozygous controls.

Hrb27CJ6/Hrb27CJ6 somatic clones in eye discs of third instar larvae are smaller than wild-type controls, display reduced cell proliferation (determined with BrdU incorporation and CycE-immunoreactivity), decreased cell density, and mild morphogenesis defects with basally displaced differentiating photoreceptor cells. A reduction in clone size is also visible in mature eyes, while mosaic discs composed mainly of Hrb27CJ6/Hrb27CJ6 cells produce overall reduced and rough eyes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference

Hrb27C[+]/Hrb27CJ6 is a suppressor | partially of eye phenotype of Rnor\PrkczUAS.act, Scer\GAL4GMR.PU

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)