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General Information
Symbol
Dmel\Gcn2dsRNA.UAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0344241
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an RNAi line that targets Gcn2.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of Gcn2dsRNA.UAS.cUa under the control of Scer\GAL4Dh44.PU increases baseline level of sucrose consumption, but does not abolishes the increased food consumption induced by dietary amino acids normally observed in controls. However, this expression does not further increase food consumption in the presence of dietary amino acids.

Expression of Gcn2dsRNA.UAS.cUa under the control of Scer\GAL4ple.PF, in combination with a Gal80[ts] transgene to restrict expression to the 16 hours prior to analysis, significantly reduces the feeding inhibition and prevents the increase in larval roaming observed when larvae are moved to an essential amino acid-deficient diet, with no effect on food intake on a rich diet, compared to controls.

Expression of Gcn2dsRNA.UAS.cUa under the control of Scer\GAL4ple.TH-D', in combination with a Gal80[ts] transgene to restrict expression to the 16 hours prior to analysis, significantly reduces the feeding inhibition observed when larvae are moved to an essential amino acid-deficient diet, compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Additional expression of GABA-B-R1VDRC.cUa in animals expressing Gcn2dsRNA.UAS.cUa under the control of Scer\GAL4ple.PF reduces larval food intake so that it is similar to that of controls on an essential amino acid-deficient diet, but significantly lower than controls on a rich diet, so that feeding inhibition is still not seen.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Gcn2dsRNA.UAS.cUa
Name Synonyms
Secondary FlyBase IDs
    References (3)