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General Information
Symbol
Dmel\bchs58M
Species
D. melanogaster
Name
FlyBase ID
FBal0344941
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Precise excision of the P{EP}EP2299 insertion present on the progenitor bchs58 chromosome. The insertion of 3bp and a deletion of 17bp within bchs is still present; this is predicted to result in a frame shift and subsequent stop codon.

The P{EP}EP2299 insertion that is present on the progenitor bchs58 chromosome has been precisely excised.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

bchs58M/Df(2L)cl7 transheterozygous larvae exhibit a mild decrease in the number of RP2 motor neurons, compared to controls.

Cultured larval neurons exhibit significantly more Atg5-positive vesicle, but no changes in the number of Atg8-positive autophagosomes, as compared to controls. However, additional expression of bchsUAS.1.GFP under the control of Scer\GAL4eve.PU leads to a severe increase in the number of autophagosomes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Enhancer of
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

Df(2L)cl7/bchs58M has RP2 motor neuron | larval stage phenotype, enhanceable by Atg7[+]/Atg7d77

Suppressed by
Statement
Reference
Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
bchs58(M)
bchs58M
Name Synonyms
Secondary FlyBase IDs
    References (2)