FB2025_01 , released February 20, 2025
Allele: Hsap\TREM213xlexAop.Tag:MYC,Tag:FLAG
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General Information
Symbol
Hsap\TREM213xlexAop.Tag:MYC,Tag:FLAG
Species
H. sapiens
Name
FlyBase ID
FBal0345085
Feature type
allele
Associated gene
Hsap\TREM2
Associated Insertion(s)
Carried in Construct
P{lexAop2-hTREM2.WT}
Key Links
Transgenic product class
cDNA
(Sekiya et al., 2018)
wild_type
(Sekiya et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Sekiya et al., 2018)
wild_type
(Sekiya et al., 2018)
Mutagen
in vitro construct
(Sekiya et al., 2018)
Progenitor genotype
Carried in construct
P{lexAop2-hTREM2.WT}
Cytology
Description

13XLexAop2 regulates expression of a cDNA encoding the full length of Hsap\TREM2 (NM_018965, RC221132) with a Tag:MYC-DDK (Tag:FLAG) tag.

(Sekiya et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
lexAop
Encoded product / tool
Hsap\TREM2
Tagged with
Tag:FLAG
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Alzheimer's disease
      modeled by Hsap\APPAβ42.UAS.Tag:SS(rPENK)
      (Sekiya et al., 2018)
      modeled by Hsap\MAPTUAS.cSa
      (Sekiya et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 2 )
       

      Co-expression of Hsap\TREM213xlexAop.Tag:MYC,Tag:FLAG and Hsap\TYROBP13xlexAop.Tag:MYC,Tag:FLAG in glia exacerbates some effects of neuronal Hsap\APPAβ42.UAS.Tag:SS(rPENK) expression.

      (Sekiya et al., 2018)

      Co-expression of Hsap\TREM213xlexAop.Tag:MYC,Tag:FLAG and Hsap\TYROBP13xlexAop.Tag:MYC,Tag:FLAG in glia exacerbates progressive neurodegeneration caused by Hsap\MAPTUAS.cSa expression in photoreceptor neurons.

      (Sekiya et al., 2018)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The co-expression of Hsap\TYROBP13xlexAop.Tag:MYC,Tag:FLAG and Hsap\TREM213xlexAop.Tag:MYC,Tag:FLAG under the control of Ecol\lexAGAD.repo does not result in significant changes in the size or gross morphology of adult brain structures, nor in the numbers of glial cells or neurons, as compared to controls; there are no signs of neurodegeneration (i.e. brain vacuolization).

      (Sekiya et al., 2018)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsap\TREM213xlexAop.Tag:MYC,Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (1)