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General Information
Symbol
Hsap\KIF5B::Hsap\RETUAS.cDa
Species
H. sapiens
Name
UAS construct of Das
FlyBase ID
FBal0346148
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulates expression of a human KIF5B-RET fusion gene cDNA, derived from a non-small-cell lung cancer (NSCLC) patient, in which the Motor Domain (MD) and Coiled Coil (CC) domain of Hsap\KIF5B is fused to the kinase (K) domain of Hsap\RET.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing Hsap\KIF5B::Hsap\RETUAS.cDa under the control of Scer\GAL4ptc.PU is nearly pupal lethal and the few adult escapers exhibit ectopic wing veins. Expression under the control of Scer\GAL4C-765 leads also to ectopic wing veins.

Wing disc epithelial cells expressing Hsap\KIF5B::Hsap\RETUAS.cDa under the control of Scer\GAL4ptc.PU shift basally, show initial signs of cell polarity defects (E-cadherin, which is normally present primarily in the apical regions of epithelia, is delocalized), and extend long processes into the neighboring region of non-expressing cells, a phenomenon not observed in controls; these cells are associated with a severely degraded basal lamina.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
NOT suppressed by
Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Hsap\KIF5B::Hsap\RETUAS.cDa
Name Synonyms
UAS construct of Das
Secondary FlyBase IDs
    References (2)