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General Information
Symbol
Dmel\sip27
Species
D. melanogaster
Name
FlyBase ID
FBal0346907
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:
Inferred boundaries of a ~1.8kb deletion reported to remove 153bp of sip2 promoter sequences, the transcription start, the translation start, and 1452/1971 bases of the sip2-RB CDS.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Deletion of 153 nucleotides of the promoter sequence, the transcription and translation sites and 75% of the coding nucleotides of sip2.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
sip27/Df(2L)Exel7029 wing discs show some bi-nucleated cells, which are virtually absent in controls, and rare incidences of micronuclei, which suggest cytokinesis failure and chromosome fragmentation or mis-segregation. Mutant wing disc cells show a slight delay in mitotic progression (time from nuclear envelope breakdown to anaphase onset), chromosome mis-segregation wherein cells cease chromosome movement sooner than controls and segregate shorter distances, and shorter duration of the midbody; there are no significant defect in interzonal microtubule density in the first 2min after anaphase onset, but further into telophase interzonal microtubules focus into a single point instead of the expected two discrete bundles of microtubules on either side of the midbody; the interzonal microtubule regions is significantly diminished and microtubules disappear much faster than controls; the contractile ring is formed and there is complete membrane constriction down to the midbody. Unlike controls, the larval brains (optic lobe and ventral nerve cord) of sip27/Df(2L)Exel7029 transheterozygotes and sip27 homozygotes show abnormal, large DNA masses that typically reside within single cells and are often surrounded by numerous micronuclei; most neuroblasts in sip27 homozygous larval brains show increased numbers of centrosomes and are polyploid, and some show synapsed chromosomes and asynchronous condensation.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Suppressed by
Statement
Reference
Enhancer of
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)