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General Information
Symbol
Dmel\HLLAA.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0347587
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of H that has been mutated to carry the amino acid replacements L245A and L247A.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing HLLAA.UAS under the control of Scer\GAL4GMR.PU results in slightly smaller eyes with a rough appearance and ectopic or absent interommatidial bristles.

Expressing HLLAA.UAS under the control of Scer\GAL4sd.PU leads to overall reduced wing area, vein thickening and ectopic nets of veins at the distal part of the longitudinal veins L2 and L5 when flies are raised at 18[o]C. At a rearing temperature of 25[o]C, wings display a further area reduction, incisions of the wing margin at the tip and ectopic bristles along ectopic veins. Under the control of Scer\GAL4bi.PU, wings are significantly smaller and display ectopic veins at the distal part of L2 and L5 (but no incisions or ectopic bristles) at 18[o]C, and more severely at 25[o]C.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expressing Su(H)UAS.cMa with HLLAA.UAS under the control of Scer\GAL4sd.PU results in rudimentary wings and ectopic bristle tufts mainly on the scutellum when flies are raised at 18[o]C, and complete wing loss with more scutellar bristles at 25[o]C. Adults are barely viable and need assistance at eclosion from the pupal case.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
HLLAA.UAS
Name Synonyms
Secondary FlyBase IDs
    References (1)