FB2025_02 , released April 17, 2025
Allele: Hsap\LATS1UAS.s
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General Information
Symbol
Hsap\LATS1UAS.s
Species
H. sapiens
Name
FlyBase ID
FBal0348185
Feature type
allele
Associated gene
Hsap\LATS1
Associated Insertion(s)
Carried in Construct
M{UAS-hLATS1.s}
Key Links
Transgenic product class
wild_type
(Matsui et al., 2019)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Matsui et al., 2019)
Mutagen
in vitro construct
(Matsui et al., 2019)
Progenitor genotype
Carried in construct
M{UAS-hLATS1.s}
Cytology
Description

UAS regulatory sequences drive expression of the short isoform of Hsap\LATS1.

(Matsui et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\LATS1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression from one copy of Hsap\LATS1UAS.s under the control of Scer\GAL4en.PU leads to a significantly smaller wing posterior compartment (measured as the posterior:whole wing area ratio), as compared to controls; this phenotype becomes more severe when Hsap\LATS1UAS.s is expressed from two copies.

      (Matsui et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Hsap\LATS1UAS.s, Scer\GAL4en.PU has abnormal size | adult stage phenotype, enhanceable by yki[+]/ykiB5

      (Matsui et al., 2019)
      Suppressed by
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      ykiB5 heterozygosity mildly enhances the small wing posterior compartment induced by the expression of Hsap\LATS1UAS.s under the control of Scer\GAL4en.PU.

      wtsx1 heterozygosity mildly suppresses the small wing posterior compartment induced by the expression of Hsap\LATS1UAS.s under the control of Scer\GAL4en.PU.

      The co-expression of Hsap\LATS1UAS.s and Hsap\YAP1UAS.cIa under the control of Scer\GAL4en.PU induces a large wing posterior compartment that is milder than upon the expression of Hsap\YAP1UAS.cIa alone, and suppresses the small wing posterior compartment that results from the expression of Hsap\LATS1UAS.s alone.

      (Matsui et al., 2019)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsap\LATS1UAS.s
      Name Synonyms
      Secondary FlyBase IDs
        References (1)