FB2025_01 , released February 20, 2025
Allele: Dmel\Adck12
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General Information
Symbol
Dmel\Adck12
Species
D. melanogaster
Name
FlyBase ID
FBal0352446
Feature type
allele
Associated gene
Dmel\Adck1
Associated Insertion(s)
TI{TI}Adck12
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Wisidagama et al., 2019)
Progenitor genotype
Associated Insertion(s)
TI{TI}Adck12
Cytology
Description

Deletion of 323 bp of Adck1 that removes the coding region for the N-terminal portion of the protein. This sequence is replaced with an eye-specific DsRed(Unk) reporter as a marker.

(Wisidagama et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:24,612,029..24,612,351 [+]
Comment:

Deletion of 323 bp of Adck1 that removes the coding region for the N-terminal portion of the protein. This sequence is replaced with an eye-specific DsRed(Unk) reporter as a marker.

(Thummel, 2020.1.23)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adck11/Adck12 second instar larvae show dorsal tracheal trunk breaks and double mouth hooks, and prematurely wander away from food.

      Adck11/Adck12 individuals rescued to adulthood by the expression of Adck1UAS.cWa under the control of Scer\GAL4da.PU do not show a developmental delay are short lived.

      Adck11/Adck12 individuals are rescued to adulthood by the expression of Adck1UAS.cWa under the control of Scer\GAL4btl.PS but are developmentally delayed, pupae are significantly smaller and adults are short lived.

      (Wisidagama et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ADCK12
      (Wisidagama et al., 2019)
      Adck12
      (Thummel, 2020.1.23)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)